منابع مشابه
Marked synergism of dimethylnitrosamine carcinogenesis in rats exposed to cadmium.
The combined carcinogenic effect of cadmium and dimethylnitrosamine (DMN) was examined in male Wistar rats, to test whether the previously observed synergism in mutagenicity between cadmium and 2 N-nitroso compounds would be paralleled by a synergism in carcinogenicity. In experiment 1, 50 five-month old rats received 18 mg DMN/kg i.p. followed by cadmium i.m. in two injections totaling either ...
متن کاملEpigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium.
Although carcinogenic metals have been known to disrupt a wide range of cellular processes the precise mechanism by which these exert their carcinogenic effects is not known. Over the last decade or two, studies in the field of metal carcinogenesis suggest that epigenetic mechanisms may play a role in metal-induced carcinogenesis. In this review we summarize the evidence demonstrating that expo...
متن کاملNrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis.
The cadmium-transformed human lung bronchial epithelial BEAS-2B cells exhibit a property of apoptosis resistance as compared with normal non-transformed BEAS-2B cells. The level of basal reactive oxygen species (ROS) is extremely low in transformed cells in correlation with elevated expressions of both antioxidant enzymes (catalase, SOD1, and SOD2) and antiapoptotic proteins (Bcl-2/Bcl-xL). Mor...
متن کاملRole of cadmium in carcinogenesis with special reference to cancer of the prostate
It has been shown in animal experiments that injections of large amounts of cadmium cause sarcoma at injection sites or testicular damage and eventually testicular tumors. Long-term exposure with small doses of cadmium has not caused testicular or prostatic tumors in experimental animals. Epidemiological studies on cadmium-exposed workers have shown excess deaths due to prostatic cancer in at l...
متن کاملJen - Fu Chiu Adaptation and Carcinogenesis The Possible Role of Cytokeratin 8 in Cadmium - Induced
Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial cells (LEC) was used to explore the mechanisms of cadmium-induced adaptation an...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2003
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2003.07.011